Duration of anesthesia, gender, height and weight seem to have little effect on MAC. Conversely, anemia, hypercarbia, hypoxia, hypothermia, hypotension (MAP < 40 mmHg), and pregnancy seem to decrease MAC. For example, MAC increases with hyperthermia and hypernatremia. Positive modulation of GABA at GABA A receptors by barbiturates or benzodiazepinesĬertain physiological and pathological states may alter MAC.co-administration of Alpha 2 agonists (dexmedetomidine) and/or opioid receptor agonists (morphine/fentanyl) can decrease the MAC.specific receptor (various agents may exhibit an additional effect through specific receptors).Exceptions to the Meyer-Overton hypothesis can result from: The hypothesis correlates lipid solubility of an anaesthetic agent with potency (1/MAC) and suggests that onset of anaesthesia occurs when sufficient molecules of the anaesthetic agent have dissolved in the cell's lipid membranes, resulting in anaesthesia. MAC is inversely related to potency, i.e. This is the Meyer-Overton hypothesis put forward in 1899–1901 by Hans Horst Meyer and Charles Ernest Overton. The MAC of a volatile substance is inversely proportional to its lipid solubility (oil:gas coefficient), in most cases. See also: Theories of general anaesthetic action
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